MBD1, MBD2 and CGBP genes may have only a limited role in human tumorigenesis.

2003 JUL 28 - (NewsRx.com & NewsRx.net) -- MBD1, MBD2 and CGBP genes may have only a limited role in human tumorigenesis.

According to recent research published in the journal Oncogene, "The genes MBD1 and MBD2 encode methyl-CpG binding proteins that suppress transcription from methylated promoters.

"In contrast, CGBP encodes a protein that binds promoters containing unmethylated CpG and stimulates transcription. All three are located on human chromosome 18q21, a region of frequent loss of heterozygosity in several cancers," wrote S. Bader and colleagues, University of Edinburgh, Molecular Medicine Center.

"These genes therefore represent candidate …